In summary

  • Swinburne researchers have discovered what is believed to be the first biomarker for anorexia nervosa: involuntary eye twitching called ‘square wave jerks’ 
  • The use of biomarkers in the screening and detection of anorexia nervosa could help prevent cases from occurring 
  • Biomarkers enable new treatment avenues for anorexia nervosa because they reveal underlying biological mechanisms involved in an illness 

Researchers from the Swinburne Anorexia Nervosa (SWAN) Research Group, together with other researchers, have discovered what is believed to be the first biomarker for anorexia nervosa. Biomarkers are typically used in the detection and treatment of physical illnesses, but never before have they been used in mental disorders. 

The challenges of diagnosis 

Anorexia nervosa is a life-threatening eating disorder that generally begins in early adolescence. It is often secretive and associated with persistent denial of symptoms and resistance to treatment. It has the highest mortality rate of all mental illnesses and low rates of recovery.  It can be hard to diagnose and even harder to treat. 

Mental illnesses are diagnosed with the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and the International Classification of Diseases. Both methods rely on patients describing symptoms and a clinician’s professional expertise. The effects of this condition and the method for diagnosing it actively work against each other. 

In a condition as time critical as anorexia nervosa, the need for accurate diagnosis and early intervention is key. And that’s where biomarkers come in. 

Tiny, unconscious eye movements are thought to be a biomarker for anorexia nervosa. Photo by Amanda Dalbjörn on Unsplash

What are biomarkers and why are they important?  

Biomarkers are characteristics of our bodies that can be measured. They include things like blood sugar, heart rate and bone density. They help us detect, screen, prevent and treat physical illnesses, but they’re not established for use in clinical practice for any mental illness. That is, until now. 

Revolutionising screening, detection and diagnosis 

Head of the SWAN Research Group, Dr Andrea Phillipou, found that a combination of a type of atypical, twitching eye movement, called ‘square wave jerks’, together with anxiety, is a promising two-element biomarker for anorexia nervosa. 

Square wave jerks were observed in people currently with anorexia nervosa, people who had recovered, and sisters of people with anorexia nervosa. The finding in sisters is critical, because it reveals there is likely a genetic, inherited link. 

New and more effective treatments 

Biomarkers also tell us about the underlying biological mechanisms involved in an illness. 

‘Eye movements use very specific brain regions, so when we see these types of atypical eye movements, we have a pretty good idea about which brain areas are not working the way they should,’ says Dr Phillipou. 

‘These areas are also involved in other functions related to anorexia nervosa – such as body image – so it gives us an idea of which brain areas we could target with treatments such as non-invasive brain stimulation.’ 

Prevention over cure 

Biomarkers are present regardless of illness state. Think of it as genetic determinism: your body is genetically pre-programmed for various outcomes – some better than others. 

‘With more research, we’re hoping that we’ll be able to use this biomarker as a screening tool to identify people who may be at risk of developing anorexia nervosa,’ says Dr Phillipou. 

‘If we’re able to do this, we’ll be able to implement things to help prevent people developing the condition in the first place.’ 

It’s a discovery that has the power to rewrite someone’s life story.

This research was carried out by researchers at Swinburne, Deakin, Monash Alfred Psychiatry Research Centre (MAPrc) and University of Toronto. 

Related articles

    • Technology
    • Sustainability

    We must rapidly decarbonise road transport – but hydrogen’s not the answer

    In order to combat the impacts of climate change, decarbonising transport is crucial. However, the focus on hydrogen in road transport is misplaced. Analysis for The Conversation by Robin Smit and Enoch Zhao, University of Technology Sydney and Hussein Dia, Swinburne University of Technology.

    Friday 19 November 2021
    • Health
    • Politics

    We identified who’s most at risk of homelessness and where they are. Now we must act, before it’s too late

    Recent research gives critical insights into how Australia can reduce homelessness by preventing it from happening in the first place. Analysis for The Conversation by Jacqueline De Vries, University of Tasmania and Deb Batterham, Christian A Nygaard and Margaret Reynolds, Swinburne University of Technology. 

    Friday 26 November 2021
    • Health

    We expected people with asthma to fare worse during COVID. Turns out they’ve had a break

    Asthma sufferers were thought to have been at greater risk of COVID-19 but recently have been found to be at a slightly lower risk of acquiring the disease, being hospitalised or dying from it. Analysis for The Conversation by Professor Bruce Thompson, Swinburne University of Technology. 

    Tuesday 23 November 2021
    • Politics
    • Sustainability

    The climate crisis gives science a new role. Here’s how research ethics must change too

    A fundamental rethinking of research ethics in light of the climate and ecological crises is needed from the COP26. Analysis for The Conversation by Alexandre Wadih Raffoul, Uppsala University, David Fopp, Stockholm University, Emma Elfversson, Uppsala University, Helen Avery, Lund University and Ryan Carolan, Swinburne University of Technology.

    Friday 05 November 2021
    • University

    Swinburne welcomes international students back to campus

    Swinburne University of Technology has welcomed the announcement that international students will be eligible to return to Australia as the borders open from 1 December 2021.

    Wednesday 24 November 2021