Centre for Human Psychopharmacology

Australian Research Council Longevity Intervention

Australia's ageing population is a significant concern facing contemporary society. The ageing process can bring decreased productivity, a higher incidence of conditions such as cardiovascular and respiratory disease and neurological conditions such as Parkinson's and Alzheimer's.

Age-related changes to our cognitive abilities occur simaltaneously with cellular degradation in the brain. Strong indications of a relationship between the onset of cognitive decline and progressive damage to the brain provides a case for protective initiatives.

This study aims to investigate whether age-related cognitive effects can be reduced by a treatment of nutraceutical compounds with either strong anti-oxidant or multi-targeted neuroprotective effects on neural cells.

The study will:

  • examine the effects of 52 week doses of Bacopa, Pycnogenol and micronutrient combination formulas (or placebo) on memory, cognitive performance and metabolic function in healthy adults aged 60–75 years
  • investigate the time course of the above measures with follow-up at 3, 6 and 12 months after commencement of interventions
  • identify health and lifestyle variables that influence health outcomes, such as perceived stress, mood, physical exercise, sleep quality, diet and nutrient levels, and personality
  • examine brain neurophysiological change through functional brain imaging (as an optional component for participants) in the first 3 months after intervention
  • explore mechanisms underpinning cognitive and cardiovascular enhancement through detailed cardiovascular (blood pressure and arterial stiffness), biochemical (safety, oxidative stress and inflammation) and genetic analysis (telomere length and key Single Nucleotide Polymorphisms related to brain function and health).

We are seeking Victorians aged 60–75 in good general health to participate in this study. Further criteria apply. Please contact us to find out more.

Study progress

The intervention study has now finished recruitment. Results are being analysed and study findings will be updated here when complete. The gut microbiome sub-study is still recruiting and you can register your interest below.


ARCLi Study team
T: +61 3 9214 5905
e: arcli@swin.edu.au

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