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Imaging the mechanism of cytolytic peptides in living cells

Description
TCytolytic peptides have antimicrobial properties but their mechanism of action is not clear. By means of fluorescence imaging we plan to visualise the interaction of peptides with bacteria and determine the mechanism of cell killing.

Aims:

  • (1) Visualise the interaction of fluorescence-tagged molecule with cells.
  • (2) Determine the mechanism of cell killing.
  • (3) Use the information to design peptides with improved selectivity for cellular target.
Supervisors