Kava is native to the South Pacific, where the rootstock been used in traditional medicine in the form of cold-water extraction to treat a range of health conditions, including anxiety, stress, muscular spasms, pain and menstrual disorders.
The most recent investigation, Kava for Generalised Anxiety Disorder (KGAD), has been funded by the National Health and Medical Research Council. This study was an 18-week randomised, double-blind, placebo-controlled multi-site clinical trial, testing the effect of a standardised pharmaceutical-grade kava extract daily versus placebo in 210 adults with diagnosed Generalised Anxiety Disorder.
The study collected structural, functional and metabolic imaging data as well as single nucleotide polymorphisms and gene expression to gauge responders and response rates, as well as data to elucidate biomarkers for Generalised Anxiety Disorder.
Data collection for this investigation is now complete.
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