Antibodies and small molecule inhibitors are the two largest classes of targeted drug therapies used in the clinic.
In collaboration with Olivia Newton-John Cancer Wellness and Research Centre researchers, Professor Andrew Scott and Dr Adam Parslow, we're using sensitive microscopic techniques to understand the mechanism by which these drugs work.
We're using uv-vis, fluorescence spectroscopies and quantum chemical calculations to probe the conformations of tyrosine kinase inhibitors with Professor Feng Wang. This information may help to improve cancer treatments.
Funding for this project is from NHMRC Project Grants in 2015, 2016 and 2017: Novel Dual Domain Targeting Strategies against ErbB Receptors and Excellerate Industry Grant “Experimental and theoretical study of tyrosine kinase inhibitors).