Understanding the mechanisms of obesity-related diseases.

Modern society has resulted in significant changes in lifestyle leading to worldwide obesity epidemic. The question of how weight may influence the risk of metabolic and cardiovascular health as well as affect the quality of life has profound implications both at individual and whole population levels.

‌We are interested in understanding the mechanisms that underlie obesity-related diseases. Some specific projects in this area include:

  • Non-alcoholic fatty liver disease is a general term that encompasses a spectrum ranging from simple steatosis to its progressive form, non-alcoholic steatohepatitis, and is among the most prevalent of liver diseases worldwide. In collaboration with our colleagues at The Hebrew University of Jerusalem, we are investigating the role of a microRNA in the regulation of lipid homeostasis which may lead to new approaches to treating fatty liver disease.
  • We employ metabolomics and lipidomics approaches to identify clinical biomarkers related to prognosis or diagnosis of a disease. In addition, given that metabolome is the functional output of all the metabolic processes in the body, it can be used to understand biochemical processes and provide mechanistic insights.
  • We are interested in understanding how different dietary fats (not just the amount of fat ingested) can influence cardiometabolic risk.
New weight stigma research

Adjunct Prof John Dixon has co-authored a paper on ‘Weight bias and stigma of obesity’ published in Nature Medicine to coincide with the first World Obesity Day on 4 March.

Contact the Iverson Health Innovation Research Institute

There are many ways to engage with us. If your organisation is dealing with a complex problem, then get in touch to discuss how we can work together to provide solutions.

Call +61 3 9214 8180