Alterations in cerebral blood flow across the adult lifespan
This study investigated differences in blood flow in the brain and cognition between older and younger people.
Studying age differences in blood flow may help researchers to better understand how the brain changes with age, which could lead to greater understanding of age-related cognitive decline in memory and thought processes.
This project invited participants aged between 55-80 and in general good health. Researchers studied the effects of ageing through brain imaging (MRI) and computerised cognitive tests. Cardiovascular measures were also recorded.
This study is now complete.
Cardiovascular function and age-associated cognitive decline
There are many examples of poor cardiovascular function affecting cognitive function. An extreme stroke can cause permanent cognitive and physical disability. Smaller and seemingly benign cardiovascular changes may contribute to age-related cognitive decline. Research suggests that improved cardiovascular function through supplementation with natural medicine may also improve cognitive functioning.
This project aimed to understand the impact of cardiovascular function including arterial stiffness, blood flow, endothelial function and other indices on age-related cognitive decline.
Through a series of studies, we investigated:
- the link between cardiovascular functioning and cognitive decline and
- cardiovascular function as a possible mechanism for improvement of cognition following supplementation with natural medicine.
These studies are now complete.
Lifestyle intervention: independent living and aged care
This research investigated the effects of an evidence-based diet and exercise program on cognitive abilities, mood, general health and perceived wellness.
The trial ran for six months with ethical approval for future follow-up assessments.
Over 200 people aged 60-90 years and living independently took part. Participants were randomly allocated to one of four groups:
- Group 1: Diet change to reflect a greater adherence to a Mediterranean diet
- Group 2: Exercise change to walk 30 to 40 minutes every second day
- Group 3: Combined diet and exercise change
- Group 4: Control group with no diet or exercise change
Assessments took take place at baseline, three months and six months. This study is now complete.
Lifestyle intervention: Measuring age-associated neurocognitive decline
The aim of this study was to understand neurocognitive ageing across the lifespan. Previous studies have shown that cognitive ageing is not a unitary process. Instead, specific areas of the brain decline more rapidly than others. These areas have served as useful constructs for assessing improvements in cognition with nutraceutical intervention.
A major outcome of this work is the Swinburne University Computerised Cognitive Ageing Battery (SUCCAB). This battery of computerised cognitive tests proved reliable on test-retest reliability, valid on decline across the lifespan and had a high construct validity on similar tests.
The tests that showed the greatest change across the lifespan also appeared to have potential to improve with supplementation of natural medicine.
Other completed and ongoing studies have used brain electrical and other neuroimaging methodologies to assess spatial-temporal patterns of neural activity in response to the performance of cognitive tasks. In particular, the Steady State Topography (SST) technique has been used extensively by our group. Again, these methods have proven useful in the assessment of response to nutraceutical supplementation.
This trial is now complete.
Cognitive ageing, nutrition and neurogenesis (CANN)
This study is investigating whether combining a fatty acid blend and flavonoids could improve brain function and memory.
Participants aged over 55 with mild memory complaints are consuming a fatty acid blend (fish oil capsule) and flavonoids (chocolate drops) daily over a 12-month period. Over four testing sessions, they are completing a series of cognition and memory tests. Some participants are also attending two optional brain imaging sessions.
This study is currently underway.
Longvida curcumin and health in older adults
Tumeric has been used for thousands of years in traditional medicine to treat a wide variety of ailments. Curcumin, the compound in turmeric that gives it its bright yellow colour, is thought to be the source of these health benefits.
In recent years, curcumin has been shown to have antioxidant, anti-inflammatory and many other valuable properties. It has been suggested that curcumin may enhance mood and mental function, yet further research is needed to investigate these potential benefits.
This study aimed to explore the effects of a curcumin supplementation on mental function, mood and health in older adults.
Participants were aged 60–85 and some had experienced age related decline in their memory or mental function. A daily supplementation was given over four weeks and participants were tested on a range of cognitive tasks as well as mood and general health.
In a subset of participants, a second stage of this study investigated the effects of curcumin supplementation on brain activity using state-of-the-art neuroimaging techniques.
This trial is now complete.
Phospholipid intervention for cognitive ageing reversal
One of the most prominent and debilitating consequences of human ageing is the cognitive decline that impacts learning and memory. There is an increased awareness of the possibility that dietary modification can alter the course of age-related cognitive decline.
Previous research suggests that a class of lipids derived from milk called phospholipids, which include phosphatidylcholine and phosphatidylserine, may benefit brain health, particularly during ageing.
This study aimed to identify whether a daily intake of phospholipids could be effective in improving cognition in older individuals who are experiencing memory difficulties.
Participants aged 55 and over with good general health took the supplement daily for six months. During several test sessions, researchers assessed participants' brain function, biomarkers associated with oxidated stress and inflammation, and cardiovascular health.
This trial is now complete.