TY - JOUR AU - Pham, Kim AU - Sacirbegovic, Faruk AU - Russell, Sarah M PY - 2014 IS - M3 - 10.3389/fimmu.2014.00026 TI - Polarised cells, polarised views: Asymmetric cell division in hematopoietic cells. JO - Frontiers in Immunology UR - http://www.frontiersin.org/Journal/Abstract.aspx?s=1177&name=t_cell_biology&ART_DOI=10.3389/fimmu.2014.00026 VL - 5 SN - 1664-3224 N2 - BACKGROUND: It has long been recognised that alterations in cell shape and polarity play important roles in coordinating lymphocyte functions. In the last decade a new aspect of lymphocyte polarity, termed Asymmetric Cell Division (ACD), has attracted much attention. ACD has previously been shown to dictate or influence many aspects of development in model organisms such as the worm and the fly, and to be disrupted in disease. Recent observations that ACD also occurs in lymphocytes led to exciting speculations that ACD might influence lymphocyte differentiation and function, and leukaemia. However, dissecting the role that ACD might play in these activities is not straightforward, and the evidence to date for a functional role in lymphocyte fate determination has been controversial. In this review, we discuss the evidence to date for ACD in lymphocytes, and how it might influence lymphocyte fate. We also discuss current gaps in our knowledge, and suggest approaches to definitively test the physiological role of ACD in lymphocytes.