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5D microscopy of cellular function

Five dimensional microscopy of cellular function in the three spatial, spectral and temporal dimensions aims to provided comprehensive understanding of diseases such as cancer at the molecular level.


Project Overview:

Group:
Aim:
The aim of this project is to investigate five dimensional microscopy of cellular function in the three spatial, spectral and temporal dimensions to provide a comprehensive understanding of diseases such as cancer at the molecular level.
Members:

Research Overview:

Cell surface receptors provide the first line of communication between cells and their external environment. Receptor malfunction has been implicated in diseases such as cancer. Our recent research has unveiled a new mechanism of receptor activation on the cell surface that involves the formation of higher-order polymeric complexes. We wish to establish the generality of this phenomenon and its implication to cell signaling and therapeutic intervention. Multidimensional microscopy allows us to view more information than a standard three dimensional (3D) microscope and gives us a better understanding of the receptors.


Project Leader:
Associate Professor
Andrew Clayton

ph: +61 3 9214 5719
aclayton@swin.edu.au

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