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Multidimensional microscopy and cell signalling

Description
The functioning of living cells is largely under the control of a series of molecule-molecule interactions called signalling networks. Individual protein molecules can be tagged and by means of fluorescence we can image their location and movement inside cells. We wish to extend this to measure multiple molecules and interactions.

Aims:

  • (1) Develop cutting-edge microscopy to image multiple molecules.
  • (2) Develop fluorescence standards and protocols.
  • (3) Apply to problem of biological significance i.e. cancer cells.
Supervisors