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New microscopic tools for cancer research

Description
The elucidation of biological signaling pathways for diverse processes such as cancer and immunity has recently been revolutionised by the development of multidimensional fluorescence microscopy. In particular, the ability to measure molecular motions and macromolecular complex formation underpins our understanding of biological systems at the molecular level. Current technology measures either static images of interaction or single point measurement of motion. What is urgently needed is a capability to image, in three dimensions, motion and interaction.

The aim of this project will be to build on our expertise in raster-image-correlation-spectroscopy (RICS) with Forster Resonance Energy Transfer (FRET) to develop new methods of imaging motion and interaction. The student will be working with advanced microscopes at the Centre for Micro-Photonics, but will also interact with biologists at the Peter MacCallum Cancer Centre to apply the new methods to problems of interest in cancer research. This is an exciting opportunity at the interface between biology and physics.

Supervisors