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Two new PhD positions in the Cell Biophysics Laboratory

Sunday November 21 2010

Enthusiastic students are sought to undertake PhD studies in the Cell Biophysics Laboratory. Two projects are being offered which involve detailed analysis and visualisation of molecule-molecule and molecule-cell interactions at the cellular level.

Associate Professor Andrew Clayton from the Centre for Micro-Photonics Cell Biophysics Laboratory is seeking two students to undertake PhD studies in the following projects.

Project 1: Multidimensional microscopy and cell signalling.

The functioning of living cells is largely under the control of a series of molecule-molecule interactions called signalling networks. Individual protein molecules can be tagged and by means of fluorescence we can image their location and movement inside cells. We wish to extend this to measure multiple molecules and interactions.


  • (1) Develop cutting-edge microscopy to image multiple molecules.

  • (2) Develop fluorescence standards and protocols.

  • (3) Apply to problem of biological significance i.e. cancer cells.

Project 2: Imaging the mechanism of cytolytic peptides in living cells.

Cytolytic peptides have antimicrobial properties but their mechanism of action is not clear. By means of fluorescence imaging we plan to visualise the interaction of peptides with bacteria and determine the mechanism of cell killing.

  • (1) Visualise the interaction of fluorescence-tagged molecule with cells.

  • (2) Determine the mechanism of cell killing.

  • (3) Use the information to design peptides with improved selectivity for cellular target.

The selected candidates must be eligible for enrollment in the Doctor of Philosophy (Science) course and are strongly encouraged to apply for relevant scholarships. PhD duration is typically three years with an an optional extension of six months. Both projects will be located at the Hawthorn campus in Melbourne, Australia.

All interested students are strongly encouraged to contact the project supervisor Assoc. Prof. Andrew Clayton before application.