Towards the Imaging of Single Biomolecules
Dr Harry Quiney
ARC Centre of Excellence for Coherent X-ray
University of Melbourne
3:30 pm Friday, 13 February 2009, EN101
(Ground Floor, EN Building), Hawthorn.
The development of short-pulse,
short-wavelength light sources that are both bright and coherent
has suggested the possibility that we may observe directly the structures
and reaction dynamics of isolated molecules. This would facilitate
the study of biological systems, such as membrane proteins, that
are largely inaccessible to conventional crystallography because
of their reluctance to form crystalline specimens.
The physics behind the proposal to image single
molecules by collecting diffraction data will be analysed. Recent
experimental XUV data obtained at DESY will be used to motivate
our discussion of the essential challenges posed by the use of fourth-generation
X-FEL light sources in diffraction imaging experiments. An outline
of the research being conducted by the Theory and modelling group
of CXS will be presented to indicate our response to these challenges.
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